Ferromagnetic nanoparticles containing biologically active alkanolamines: preparation and properties

I. Segal¹ - A. Zablotskaya¹ - E. Lukevics¹ - M. Maiorov² - D. Zablotsky²

¹ Latvian Institute of Organic Synthesis, 21 Aizkraukles street, Riga LV-1006, Latvia
² Institute of Physics, University of Latvia, 32 Miera street, Salaspils, LV-2169, Latvia

Abstract
The objective of the present study is to investigate the possibility of sorption on ultrafine magnetic particles of some model biologically active organosilicon alkanolamines, structural analogs of natural biologically active substances, choline and colamine, with increased lipophilicity. Double-coated ferromagnetic samples containing oleic acid, as a first layer, and organosilicon alcanolamines, as a second layer, were obtained and characterized by their physical/chemical (sorption and magnetisation) and biological (toxicity and cytotoxicity) properties. The present results clearly reveal the sorption of the biologically active alkanolamines on the surface of magnetic particles and a principal possibility to coat magnetite directly with biologically active alkanolamines, creating a mono-layer cover. The data presented in the study of cytotoxic properties of the newly obtained ferromagnetic nanoparticles show that it is reasonable to investigate such systems as potential cytotoxic agents. Tables 3, Figs 3, Refs 16.