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Aqueous phase transfer of oleic acid coated iron oxide nanoparticles: influence of solvents and surfactants on stability and pharmaceutical applications of ferrofluid

M. Anwar1 - M. Asfer2 - S. Akhter1 - S. Mohapatra3 - M. H. Warsi1 - N. Jain1 - N. Mallick1 - G. K. Jain1 - A. Ali1 - P. K. Panigrahi2 - F. J. Ahmad1

1 Nanomedicine Laboratory, Department of Pharmaceutics, Hamdard University, New Delhi, India
2 Department of Mechanical Engineering, IIT, Kanpur, U.P, India
3 Sunderdeep Pharmacy College, Ghaziabad, U.P., India

In this work, iron oxide nanoparticles were prepared by a classical co-precipitation method in an inert atmosphere. In the first step, iron oxide nanoparticles were synthesized, coated with oleic acid (5--50\%) and its dispersions in different organic solvents (n-hexane, n-heptane and n-octane) were prepared. In the second step, a ferrofluid was obtained by a mini-emulsion process with the aid of different surfactants: sodium dodecyl sulphate (SDS), polysorbate 20 (tween 20), sorbitan monolaurate (span 20), poloxamer 188, poloxamer 407, Polyoxyl 23 lauryl ether (brij 35), Polyoxyl 40 stearate (myrj 52), vitamin E polyethylene glycol succinate (vitamin E TPGS) and docusate sodium. Characterization of oleic acid coated iron oxide nanoparticles were done by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray powder diffraction (XRD). Stability study of the aqueous ferrofluid was performed by measuring the particle size and polydispersity index within a storage period of six months. Clinical application of ferrofluid in targeted drug delivery systems was also discussed with respect to different surfactants. Tables 1, Figs 3, Refs 5.

Magnetohydrodynamics 49, No. 3/4, 339-343, 2013 [PDF, 0.70 Mb]

Copyright: Institute of Physics, University of Latvia
Electronic edition ISSN 1574-0579
Printed edition ISSN 0024-998X