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MFBSAs as therapeutic agents targeting insulin amyloidosis

K. Siposova1 - M. Kubovċikova1 - Z. Bednarikova1, 2 - M. Koneracka1 - V. Závišová1 - P. Kopċanský1 - Z. Gazova1

1 Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001 Košice, Slovakia
2 Institute of Chemistry, Faculty of Science, Pavol Jozef Safarik University, Moyzesova 11, 040 01, Košice, Slovakia

We investigated the ability of albumin magnetic fluids (MFBSAs) consisting of Fe3O4 nanoparticles (NPs) stabilized by sodium oleate and modified by different amounts of bovine serum albumin (BSA) to destroy insulin amyloid fibrils. Moreover, we studied the anti-amyloid effect of MFBSAs on cells affected by insulin amyloids. Tables 1, Figs 2, Refs 9.

Magnetohydrodynamics 49, No. 3/4, 560-563, 2013 [PDF, 0.31 Mb]

Copyright: Institute of Physics, University of Latvia
Electronic edition ISSN 1574-0579
Printed edition ISSN 0024-998X