Ferrifluids cytotoxity excitation by an AC magnetic field

N. A. Brusentsov¹ - E. Yu. Filinova¹ - T. G. Nikolaeva¹ - A. Yu. Baryshnikov¹ - V. V. Gogosov² - T. N. Brusentsova² - L. Kh. Komissarova³ - A. F. Mirognov⁴ - A. V. Lubeshkin⁴ - L. I. Shumakov⁵

¹ Russian N.N. Blokhin Memorial Cancer Research Center RAMS, Moscow, Russia
² Institute of Mechanics, Moscow State University, Moscow, Russia
³ Institute of Biochemical Physics RAS, Moscow, Russia
⁴ Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia
⁵ All-Russian Radiotechnical Research Institute, Moscow, Russia

Abstract
The tumor cells murine ascitic limpholeukosis and adherent human carcinoma ovarii alone and with reagents (dextran-ferrite, photogem, histidine, and its combinations) were placed in the center of a coil and exposed to the AC magnetic field in the dark for AC induction hyperthermia and magnetosensitization. A count of the viable cells under different conditions (magnetosensitization, temperature, photogem concentration, and so forth) were investigated. The AC magnetic field cells damage enhancement by photogem at +37^°C and simultaneous thermal- and AC magnetic field cell damage enhancements by photogem at +41^°C were effectively suppressed by adding an singlet oxygen scavenger, histidine. Tables 6, Figs 3, Refs 17.