Electronic edition ISSN 1574-0579

MFBSAs as therapeutic agents targeting insulin amyloidosis

K. Siposova¹ , M. Kubovċikova¹ , Z. Bednarikova^{1, 2} , M. Koneracka¹ , V. Závišová¹ , P. Kopċanský¹ , Z. Gazova¹

¹ Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001 Košice, Slovakia
² Institute of Chemistry, Faculty of Science, Pavol Jozef Safarik University, Moyzesova 11, 040 01, Košice, Slovakia

Abstract
We investigated the ability of albumin magnetic fluids (MFBSAs) consisting of Fe₃O₄ nanoparticles (NPs) stabilized by sodium oleate and modified by different amounts of bovine serum albumin (BSA) to destroy insulin amyloid fibrils. Moreover, we studied the anti-amyloid effect of MFBSAs on cells affected by insulin amyloids. Tables 1, Figs 2, Refs 9.